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KMID : 1377020230200030371
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Tissue Engineering and Regenerative Medicine
2023 Volume.20 No. 3 p.371 ~ p.387
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Nanoparticle-Based Chimeric Antigen Receptor Therapy for Cancer Immunotherapy
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Shin Seung-Yong
Lee Pyunghwajun
Han Ji-Eun
Jin Sung-Yup
Lee Moon-Ok
Park Dae-Hwan
Paik Tae-Jong
Min Jun-Hong
Park Chun-Gwon
Park Woo-Ram
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Abstract
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Adoptive cell therapy with chimeric antigen receptor (CAR)-engineered T cells (CAR-Ts) has emerged as an innovative immunotherapy for hematological cancer treatment. However, the limited effect on solid tumors, complex processes, and excessive manufacturing costs remain as limitations of CAR-T therapy. Nanotechnology provides an alternative to the conventional CAR-T therapy. Owing to their unique physicochemical properties, nanoparticles can not only serve as a delivery platform for drugs but also target specific cells. Nanoparticle-based CAR therapy can be applied not only to T cells but also to CAR-natural killer and CAR-macrophage, compensating for some of their limitations. This review focuses on the introduction of nanoparticle-based advanced CAR immune cell therapy and future perspectives on immune cell reprogramming.
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KEYWORD
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Chimeric antigen receptor (CAR), Nanoparticle, Genetic engineering, Immune cell reprograming, Cancer immunotherapy
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